Tay-Sachs disease

1. Tay-Sachs Disease: From Clinical Description to Molecular Defect / Michael M. Kaback and Robert J. Desnick

2. Barney Sachs and the History of the Neuropathologic Description of Tay-Sachs Disease / Daniel P. Perl

3. Early Epidemiologic Studies of Tay-Sachs Disease / Stanley M. Aronson

4. Identification of the Accumulated Ganglioside / Lars Svennerholm

5. Discovery of the Hexosaminidase Isoenzymes / Donald Robsinson and John L. Stirling

6. Tay-Sachs Disease: The Search for the Enzymatic Defect / Roscoe O. Brady

7. Discovery of [beta]-Hexosaminidase A Deficiency in Tay-Sachs Disease / Shintaro Okada and John S. O'Brien

8. G[subscript M2]-Gangliosidoses and the Elucidation of the [beta]-Hexosaminidase System / Konrad Sandhoff

9. Subunit Structure of the Hexosaminidase Isozymes / Ernest Beutler

10. Molecular Genetic of the [beta]-Hexosaminidase Isoenzymes: An Introduction / Edwin H. Kolodny

11. Cloning the [beta]-Hexosaminidase Genes / Richard L. Proia

12. Search for the Genetic Lesion in Ashkenazi Jews with Classic Tay-Sachs Disease / Rachel Myerowitz

13. [beta]-Hexosaminidase Story in Toronto: From Enzyme Structure to Gene Mutation / Don J. Mahuran and Roy A. Gravel

14. Biosynthesis of Normal and Mutant [beta]-Hexosaminidases / Elizabeth F. Neufeld and Alessandra d'Azzo

15. Recognition and Delineation of [beta]-Hexosaminidase [alpha]-Chain Variants: a Historical and Personal Perspective / Kunihiko Suzuki

16. Late-Onset G[subscript M2] Gangliosidosis and Other Hexosaminidase Mutations among Jews / Ruth Navon

17. Naturally Occurring Mutations in G[subscript M2] Gangliosidosis: A Compendium / Barbara Triggs-Raine, Don J. Mahuran and Roy A. Gravel

18. Targeting the Hexosaminidase Genes: Mouse Models of the G[subscript M2] Gangliosidoses / Richard L. Proia

19. Molecular Epidemiology of Tay-Sachs Disease / Neil Risch

20. Screening and Prevention in Tay-Sachs Disease: Origins, Update, and Impact / Michael M. Kaback

21. Not Preventing - Yet, Just Avoiding Tay-Sachs Disease / Charles R. Scriver

22. Experiences in Molecular-Based Prenatal Screening for Ashkenazi Jewish Genetic Diseases / Christine M. Eng and Robert J. Desnick

23. Dor Yeshorim Story: Community-Based Carrier Screening for Tay-Sachs Disease / Josef Ekstein and Howard Katzenstein

24. Tay-Sachs Disease and Preimplantation Genetic Diagnosis / Christoph Hansis and Jamie Grifo

25. Treatment of G[subscript M2] Gangliosidosis: Past Experiences, Implications, and Future Prospects / Mario C. Rattazzi and Kostantin Dobrenis

26. Tay-Sachs Disease: Psychologic Care of Carriers and Affected Families / Leslie Schweitzer-Miller

27. Future Perspectives for Tay-Sachs Disease / Robert J. Desnick and Michael M. Kaback.